Mathematical processing of absorption as green smart spectrophotometric methods for concurrent assay of hepatitis C antiviral drugs, Sofosbuvir and Simeprevir: application to combined pharmaceutical dosage forms and evaluation of the method greenness

Autor:	Sayed M. Derayea, Ahmed A. Abu-hassan, Ahmed A. Hamad, Walid E. Eltoukhi, Amal E. Hamad, Bassam Shaaban Mohammed
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Simeprevir Sofosbuvir Iso-absorptive point method Ratio subtraction method Dual wavelength method Combined pharmaceutical dosage forms Chemistry QD1-999
Zdroj:	BMC Chemistry, Vol 17, Iss 1, Pp 1-10 (2023)
Druh dokumentu:	article
ISSN:	2661-801X
DOI:	10.1186/s13065-023-00984-5
Popis:	Abstract The present work was developed to create three rapid, simple, eco-friendly, cheap spectrophotometric methods for concurrent assay of Sofosbuvir (SOF) and Simeprevir (SMV) in their pure, laboratory prepared mixture and pharmaceutical dosage form with high degree of accuracy and precision. Three methods were developed including iso-absorptive point, ratio subtraction and dual wavelength. The linear range of the proposed methods was 3.0–50.0 and 2.0–50.0 µg mL−1 for SMV and SOF, respectively. The proposed methods were validated according to ICH guidelines in terms of linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed approach is highly simple and the procedure is environmentally green making it suitable for the drug analysis in routine works.
Databáze:	Directory of Open Access Journals
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