Derajat Ekspresi Fibroblast Activation Protein Pada Cancer-Associated Fibroblast Karsinoma Kolorektal
| Autor: | Vonny Amalia |
|---|---|
| Jazyk: | English<br />Indonesian |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Majalah Kedokteran Andalas, Vol 46, Iss 11, Pp 1839-1850 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0126-2092 2442-5230 1839-1850 |
| DOI: | 10.25077/mka.v46.i11.p1839-1850.2024 |
| Popis: | Objective: to determine the degree of expression of Fibroblast Activation Protein in Cancer Associated Fibroblasts of colorectal carcinoma. Methods: descriptive study with a cross sectional research design. Using 36 paraffin blocks of CRC cases that met the inclusion criteria. FAP expression was assessed through immunohistochemical staining with anti-FAP and histopathological data were recorded in the form of depth invasion, degree of differentiation, lymphovascular invasion and lymph node metastatic status. Results: FAP in CAFs showed a high expression in most cases (52.8%). High-grade expression of FAP more common at T3-T4 depth of invasion, low-grade differentiation, CRC without lymphovascular invasion and CRC without lymph node metastases. Conclusion: there are variations in the expression of FAP as a marker of CAFs in colorectal carcinoma histopathology features. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|