Diagnostic and prognostic significance of circulating secreted frizzled‐related protein 5 in colorectal cancer

Autor:	Runhao Li, Saifei Liu, Kenny Yeo, Suzanne Edwards, Man Ying Li, Ryan Santos, Sima Kianpour Rad, Fangmeinuo Wu, Guy Maddern, Joanne Young, Yoko Tomita, Amanda Townsend, Kevin Fenix, Ehud Hauben, Timothy Price, Eric Smith
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	colorectal cancer diagnosis plasma biomarker prognosis SFRP5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 13, Iss 11, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.7352
Popis:	Abstract Background Secreted Frizzled‐Related Protein 5 (SFRP5) modulates Wnt signalling pathways, affecting diverse biological processes. We assessed the diagnostic and prognostic value of circulating SFRP5 (cSFRP5) in colorectal cancer (CRC) Methods Plasma cSFRP5 concentrations were measured using enzyme‐linked immunosorbent assay (ELISA) in healthy donors (n = 133), individuals diagnosed with CRC (n = 449), colorectal polyps (n = 85), and medical conditions in other organs including cancer, inflammation, and benign states (n = 64). Results Patients with CRC, polyps, and other conditions showed higher cSFRP5 levels than healthy individuals (p
Databáze:	Directory of Open Access Journals
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