Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children

Autor: Fei Fan, Jun Lv, Qianyuan Yang, Fei Jiang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Clinical Respiratory Journal, Vol 17, Iss 7, Pp 607-617 (2023)
Druh dokumentu: article
ISSN: 1752-699X
1752-6981
DOI: 10.1111/crj.13620
Popis: Abstract Background To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of disease. Methods The study included 265 children with MPP and 230 children with NMPP in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from 2020 to 2021. The children with MPP included RMPP (n = 85) and GMPP (n = 180). Demographic and clinical characteristics, laboratory and imaging findings of all children were measured as baseline data within 24 h after admission and the differences between MPP and NMPP, RMPP and GMPP patients were compared. ROC curves were used to evaluate the diagnostic and predictive value of different indicators for RMPP. Results Fever duration and hospital stay in children with MPP were longer than those with NMPP. The number of patients with imaging features of pleural effusion, lung consolidation and bronchopneumonia in MPP group was significantly higher than that in NMPP group. Compared with NMPP group, the levels of C‐reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), lactic dehydrogenase (LDH), prothrombin time (PT), fibrinogen (FIB) and D‐dimer and inflammatory cytokines (interleukin [IL]‐6, IL‐8, IL‐10 and IL‐1β) in MPP group were significantly higher (P
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