Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Autor: Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin, Maria K. Lehtinen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20666-3
Popis: Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice.
Databáze: Directory of Open Access Journals