Para-Carboxy Modified Amphiphilic Calixarene, Self-Assembly and Interactions with Pharmaceutically-Relevant Molecules
| Autor: | Dirk Elend, Uwe Pieles, Patrick Shahgaldian |
|---|---|
| Jazyk: | German<br />English<br />French |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 64, Iss 1-2 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| DOI: | 10.2533/chimia.2010.45 |
| Popis: | The self-assembly properties of the amphiphilic 5,11,17,23-tetra-carboxy-25,26,27,28-tetradodecyloxycalix[4]arene have been investigated at the air–water interface as monomolecular Langmuir layers and in water. The interactions of this amphiphile with salicylic acid (SA), acetyl-salicylic acid (ASA) and acetaminophene (APAP) have been studied at the air–water interface by means of the Langmuir balance technique. It has been demonstrated that the calix-arene molecules, when self-assembled as Langmuir monolayers, have the ability to interact with all the tested compounds. While APAP causes a stabilization of the monolayer, ASA and SA cause a slight loss of stability and a drastic change of the compressibility of the monolayer. The study of the self-assembly properties of the title compound in water revealed that this amphiphile can be self-assembled as solid lipid nanoparticles (SLNs). The atomic force microscopy investigations of the colloidal suspension, spread on a solid surface and dried, revealed the coexistence of the SLNs with layered structures. |
| Databáze: | Directory of Open Access Journals |
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