| Autor: |
Michelle Mendanha Mendonça, Kellen Rosa da Cruz, Denise da Silva Pinheiro, Gean Carlos Alves Moraes, Patricia Maria Ferreira, Marcos Luiz Ferreira-Neto, Eduardo Sérgio da Silva, Reggiani Vilela Gonçalves, Gustavo Rodrigues Pedrino, James O. Fajemiroye, Carlos Henrique Xavier |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Hematology, Transfusion and Cell Therapy, Vol 44, Iss 2, Pp 235-245 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2531-1379 |
| DOI: |
10.1016/j.htct.2022.01.005 |
| Popis: |
Introduction: The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective: Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results: Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion: The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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