Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease

Autor: Chin-Chuan Chang, Ming-Hui Yang, Chih-Ting Liu, Hsiu-Lan Chu, Chia-Yang Lin, Wei-Jheng Yen, Chao-Yu Chung, Sheng-Yow Ho, Yu-Chang Tyan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Diagnostics, Vol 10, Iss 10, p 772 (2020)
Druh dokumentu: article
ISSN: 2075-4418
83782214
DOI: 10.3390/diagnostics10100772
Popis: This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (p = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%.
Databáze: Directory of Open Access Journals
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