| Autor: |
Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann, Thumbi Ndung’u |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1741-7015 |
| DOI: |
10.1186/s12916-020-01529-6 |
| Popis: |
Abstract Introduction Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed the plasma cytokines kinetics, and their associations with virological and immunological parameters, in a well-characterized AHI cohort where participants were diagnosed before peak viremia. Methods Blood cytokine levels were measured using Luminex and ELISA assays pre-infection, during the hyperacute infection phase (before or at peak viremia, 1–11 days after the first detection of viremia), after peak viremia (24–32 days), and during the early chronic phase (77–263 days). Gag-protease-driven replicative capacities of the transmitted/founder viruses were determined using a green fluorescent reporter T cell assay. Complete blood counts were determined before and immediately following AHI detection before ART initiation. Results Untreated AHI was associated with a cytokine storm of 12 out of the 33 cytokines analyzed. Initiation of ART during Fiebig stages I–II abrogated the cytokine storm. In untreated AHI, virus replicative capacity correlated positively with IP-10 (rho = 0.84, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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