| Autor: |
Joshua K Park, Shantanu Bafna, Iain S Forrest, Áine Duffy, Carla Marquez-Luna, Ben O Petrazzini, Ha My Vy, Daniel M Jordan, Marie Verbanck, Jagat Narula, Robert S Rosenson, Ghislain Rocheleau, Ron Do |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
eLife, Vol 12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2050-084X |
| DOI: |
10.7554/eLife.80560 |
| Popis: |
Background: Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems. Methods: Here, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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