No predialysis treatment of blood primes in pediatric continuous kidney replacement therapy

Autor: Hiroyuki Nagafuchi, Kenta Shono, Hiroyuki Shimizu, Kaori Yamada, Aya Kajihama, Sakura Minami, Kyosuke Sasaki
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Renal Replacement Therapy, Vol 9, Iss 1, Pp 1-7 (2023)
Druh dokumentu: article
ISSN: 2059-1381
DOI: 10.1186/s41100-023-00482-3
Popis: Abstract Background Pediatric continuous kidney replacement therapy (CKRT) uses blood as the priming fluid in the CKRT circuit to prevent hemodilution and hypotension and is dialyzed using a dialysate before the start of CKRT. This study aimed to investigate the safety of CKRT using a protocol of no predialysis after blood priming in underweight infants, based on hemodynamic and laboratory data changes. Methods This single-center retrospective cohort study included children weighing 95% of the levels before extracorporeal circulation. Moreover, potassium levels, which were not significantly different between extracorporeal circulation and dialysis initiation (p = 1.000), were significantly decreased after dialysis (p = 0.046). Lactate and hematocrit did not significantly change either before dialysis (p = 0.131 and 0.071, respectively) or after dialysis compared to the time of extracorporeal circulation (p = 1.000 and 0.591, respectively). Conclusions CKRT, using our protocol, could be safely performed without predialysis treatment of blood primes in children weighing
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