| Autor: |
Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Isabela Peixoto Martins, Audrei Pavanello, Júlio Cezar de Oliveira, Kelly Valério Prates, Rosiane Aparecida Miranda, Claudinéia Conationi da Silva Franco, Rodrigo Mello Gomes, Flávio Andrade Francisco, Vander Silva Alves, Douglas Lopes de Almeida, Veridiana Mota Moreira, Kesia Palma-Rigo, Elaine Vieira, Gabriel Sergio Fabricio, Marcos Ricardo da Silva Rodrigues, Wilson Rinaldi, Ananda Malta, Paulo Cezar de Freitas Mathias |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-017-07395-2 |
| Popis: |
Abstract Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life. To test these hypotheses, pregnant rats were randomly assigned into 2 groups: Sedentary and Exercised, low intensity, on a rodent treadmill at 30% VO2Max /30-minute/session/3x/week throughout pregnancy and the lactation. Male offspring were raised in small litters (SL, 3 pups/dam) and normal litters (NL, 9 pups/dam) as models of early overnutrition and normal feed, respectively. Exercised mothers showed low mesenteric fat pad stores and fasting glucose and improved glucose-insulin tolerance, VO2max during lactation and sympathetic activity. Moreover, the breast milk contained elevated levels of insulin. In addition, SL of sedentary mothers presented metabolic dysfunction and glucose and insulin intolerance and were hyperglycemic and hyperinsulinemic in adulthood. SL of exercised mothers showed lower fat tissue accretion and improvements in glucose tolerance, insulin sensitivity, insulinemia and glycemia. The results suggest that maternal exercise during the perinatal period can have a possible reprogramming effect to prevent metabolic dysfunction in adult rat offspring exposed to early overnutrition, which may be associated with the improvement in maternal health caused by exercise. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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