Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Autor:	Eric D. Cassmann, S. Jo Moore, Justin J. Greenlee
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	chronic wasting disease CWD chronic wasting disease agent prions and related diseases transmissible spongiform encephalopathies animal diseases Medicine Infectious and parasitic diseases RC109-216
Zdroj:	Emerging Infectious Diseases, Vol 27, Iss 12, Pp 3156-3158 (2021)
Druh dokumentu:	article
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2712.204978
Popis:	Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.
Databáze:	Directory of Open Access Journals
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