An integrated approach to assess the complications of deforming osteoarthritis in sports medicine
| Autor: | I. S. Vorobyova, V. B. Borodulin, V. V. Nikitina |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Спортивная медицина: наука и практика, Vol 10, Iss 4, Pp 15-21 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2223-2524 2587-9014 |
| DOI: | 10.47529/2223-2524.2020.4.8 |
| Popis: | Objective: prognosis of thromboembolic complications using clinical diagnostic markers.Materials and methods. The study involved 151 patients who underwent total arthroplasty (TA) of large joints of the lower extremities. Blood serum was studied at the patient’s admission to the hospital, after surgery, and at discharge from the hospital. The following parameters were determined: cell-molecular marker vascular endothelial growth factor (VEGF), a genetic study was performed using the “Plasma screen. Plasma factors of the blood clotting system”. The content of VEGF was determined in blood serum using solid-phase enzyme immunoassay. The effectiveness of diagnostics based on sensitivity and specificity analysis was considered by constructing a ROC analysis at different points of separation of the values of the studied indicators.Results. Diagnostic significance of VEGF and the efficiency of determining PAI-1 were determined. In patients with elevated VEGF values (>183.6 pg/ml), PAI-1 gene polymorphism was detected, which reduces the fibrinolytic activity of the blood system and increases the risk of coronary disorders. This is especially important for patients in a hospital with a large number of risk factors for the development of VTEC due to prolonged immobilization of the limb. The study made it possible to determine that with VEGF values up to 183.6 pg/ml, a low probability of thromboembolic complications is predicted, and with values above 183.6 pg/ml — high.Conclusion. The course of DOA in athletes may be complicated by surgical intra-articular interventions of traumatological and orthopedic profile, which does not exclude the development of VTEO, significantly complicating drug therapy and the rehabilitation period. The presented data show that the determination of VEGF, 5G-675 4G polymorphism of the PAI 1 gene in blood serum can be used to assess the risk of venous thromboembolic complications (VTE), contributing to modern informative diagnostics, improving the quality of life of athletes and prolonging their sports career. |
| Databáze: | Directory of Open Access Journals |
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