| Autor: |
Keishi Sugino, Hirotaka Ono, Mikako Saito, Seiji Igarashi, Atsuko Kurosaki, Eiyasu Tsuboi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Respirology Case Reports, Vol 10, Iss 4, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2051-3380 |
| DOI: |
10.1002/rcr2.925 |
| Popis: |
Abstract A 79‐year‐old former smoking Japanese man was admitted to our hospital with a 2‐year history of dry cough and dyspnoea on exertion. High‐resolution computed tomography of the chest revealed reticulation and perilobular opacity with bronchial wall thickening and ground‐glass opacities (GGOs) in both lungs, in addition to subpleural dense consolidation (pleuroparenchymal fibroelastosis‐like lesion; PPFE‐like lesion) predominantly in the bilateral upper lobes. Serum immunoglobulin G4 (IgG4) was elevated (348 mg/dl). Lung biopsy specimens obtained by video‐assisted surgery revealed a mixture of usual interstitial pneumonia (IP) and non‐specific IP pattern admixed with PPFE. In addition, immunohistochemical staining of IgG4 showed numerous IgG4‐positive plasma cells. Consequently, he was diagnosed with IgG4‐positive IP associated with PPFE. We initiated a combination therapy with prednisolone and cyclosporine as a calcineurin inhibitor. During prednisolone tapering, his clinical conditions and GGOs improved gradually over 12 months. However, reticular opacities and PPFE‐like lesions remained unchanged, and pulmonary function test findings slightly deteriorated. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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