| Autor: |
Lahogue Caroline, Pinault Didier |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Translational Neuroscience, Vol 12, Iss 1, Pp 282-296 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2081-6936 |
| DOI: |
10.1515/tnsci-2020-0157 |
| Popis: |
During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies) during the wake–sleep cycle. Neural oscillations are electrobiomarkers of the connectivity state within systems. A single-systemic administration of ketamine, a non-competitive NMDA glutamate receptor antagonist, transiently reproduces the oscillopathies with a clinical picture reminiscent of the psychosis prodrome. This acute pharmacological model may help the research and development of innovative treatments against psychotic transition. Transcranial electrical stimulation is recognized as an appropriate non-invasive therapeutic modality since it can increase cognitive performance and modulate neural oscillations with little or no side effects. Therefore, our objective was to set up, in the sedated adult rat, a stimulation method that is able to normalize ketamine-induced increase in gamma-frequency (30–80 Hz) oscillations and decrease in sigma-frequency (10–17 Hz) oscillations. Unilateral and bipolar frontoparietal (FP), transcranial anodal stimulation by direct current ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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