Translational Models in Glioma Immunotherapy Research

Autor:	Alexander L. Ren, Janet Y. Wu, Si Yeon Lee, Michael Lim
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	immunotherapy glioma syngeneic murine glioma lines genetically engineered mouse models humanized mice organoids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Current Oncology, Vol 30, Iss 6, Pp 5704-5718 (2023)
Druh dokumentu:	article
ISSN:	1718-7729 1198-0052
DOI:	10.3390/curroncol30060428
Popis:	Immunotherapy is a promising therapeutic domain for the treatment of gliomas. However, clinical trials of various immunotherapeutic modalities have not yielded significant improvements in patient survival. Preclinical models for glioma research should faithfully represent clinically observed features regarding glioma behavior, mutational load, tumor interactions with stromal cells, and immunosuppressive mechanisms. In this review, we dive into the common preclinical models used in glioma immunology, discuss their advantages and disadvantages, and highlight examples of their utilization in translational research.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/11a41bd6dc994db281d5568fe155436b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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