Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

Autor: Larissa Lavorato Lima, Rebeca Mól Lima, Annelisa Farah da Silva, Antônio Márcio Resende do Carmo, Adilson David da Silva, Nádia Rezende Barbosa Raposo
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: The Scientific World Journal, Vol 2013 (2013)
Druh dokumentu: article
ISSN: 1537-744X
DOI: 10.1155/2013/274643
Popis: This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P
Databáze: Directory of Open Access Journals
Externí odkaz: