| Autor: |
Milovanović Mirjana, Milosavljević Miloš, Đorđe Marjanović S, Trailović M Saša, Vučinić Marijana, Nedeljković Trailović Jelena, Marković Maja, Đurđević Dragan |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Acta Veterinaria, Vol 66, Iss 4, Pp 478-488 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1820-7448 |
| DOI: |
10.1515/acve-2016-0041 |
| Popis: |
Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using the rota-rod test. Carvacrol administered PO in pre-treatment (45 min. prior to formalin) at a single dose of 50, 75 and 100 mg /kg BW, in the male, 50 and 100 mg /kg BW, in female rats caused a dose-dependent antinociceptive effect. This effect of carvacrol was significantly higher (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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