Bio efficacy, and photocatalytic activity of the silver nanoparticles synthesized from Cryptolepis buchanani leaf extract
| Autor: | Sudipta Panja, Anutosh Patra, Kalyani Khanra, Indranil Choudhuri, Bikash Pati, Nandan Bhattacharyya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Nanomedicine Research Journal, Vol 5, Iss 4, Pp 369-377 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2476-3489 2476-7123 |
| DOI: | 10.22034/nmrj.2020.04.009 |
| Popis: | The objective of the study is to synthesis silver nanoparticles from the leaf extract of Cryptolepis buchanani, a medically important plant,by green synthesis method. The synthesized nanoparticles have an average size of 17.05±5.27 nm, crystalline in nature with face cantered cubic structure, and positive surface charge. The nanoparticles are biologically active. It killed > 90 % of HeLa cells at 25 μg mL-1 concentration in-vitro cell cytotoxicity assay, with a LD50 value of 3.98 μg mL-1. The nanoparticles are less effective on MCF-7 and HEK-293 cell line, almost 70 % of MCF-7 populations were survived at highest concentration of 25 μg mL-1. In case of HEK-293 it killed almost 78 % of cells at the same concentration with a 9.45 μg mL-1 LD50 value. The synthesized nanoparticle lysed less than 2.5 % of red blood cells at 10 μg mL-1 concentration in-vitro. The nanoparticles degraded >90 % of methylene blue dye in presence of light in 8.5 h. These properties of the synthesized nanoparticles are unique, and make it promising for its future potential applications. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|