| Autor: |
Chika K. Onwuamah, Jonathan Okpokwu, Rosemary Audu, Godwin Imade, Seema T. Meloni, Azuka Okwuraiwe, Philippe Chebu, Adesola Z. Musa, Beth Chaplin, Ibrahim Dalhatu, Oche Agbaji, Jay Samuels, Oliver Ezechi, Mukhtar Ahmed, Georgina Odaibo, David O. Olaleye, Prosper Okonkwo, Babatunde Lawal Salako, Elliot Raizes, Chunfu Yang, Phyllis J. Kanki, Emmanuel O. Idigbe |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BMC Microbiology, Vol 20, Iss 1, Pp 1-9 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2180 |
| DOI: |
10.1186/s12866-020-1706-1 |
| Popis: |
Abstract Background We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. We characterized their drug resistance mutations (DRM) and adherence profiles to learn how to better manage HIV drug resistance. A retrospective cohort study utilizing clinical data and stored samples. Patients received ART at three Nigerian treatment centres. Plasma samples stored when they were in VF were genotyped. Result Of 126 patients with samples available, 57 were successfully genotyped. From ART initiation, the proportion of patients with adherence ≥90% increased steadily from 54% at first high viral load (VL) to 67% at confirmed VF, and 81% at time of re-suppressed VL. Sixteen (28%) patients had at least one DRM. Forty-six (81%) patients had full susceptibility to the three drugs in their first-line (1 L) regimen. Thirteen (23%) were resistant to at least one antiretroviral drug but three were resistant to drugs not used in Nigeria. Ten patients had resistance to their 1 L drug(s) and six were fully susceptible to the three drugs in the recommended second-line regimen. Conclusion This cohort had little drug resistance mutations. We conclude that if adherence is not assured, patients could exhibit virologic failure without having developed mutations associated with drug resistance. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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