The Potential Role of Human Milk Oligosaccharides in Irritable Bowel Syndrome
| Autor: | Patricia Sanz Morales, Anisha Wijeyesekera, Margaret Denise Robertson, Peter P. J. Jackson, Glenn R. Gibson |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Microorganisms, Vol 10, Iss 12, p 2338 (2022) |
| Druh dokumentu: | article |
| ISSN: | 10122338 2076-2607 |
| DOI: | 10.3390/microorganisms10122338 |
| Popis: | Irritable Bowel Syndrome (IBS) is the most common gastrointestinal (GI) disorder in Western populations and therefore a major public health/economic concern. However, despite extensive research, psychological and physiological factors that contribute to the aetiology of IBS remain poorly understood. Consequently, clinical management of IBS is reduced to symptom management through various suboptimal options. Recent evidence has suggested human milk oligosaccharides (HMOs) as a potential therapeutic option for IBS. Here, we review literature concerning the role of HMOs in IBS, including data from intervention and in vitro trials. HMO supplementation shows promising results in altering the gut microbiota and improving IBS symptoms, for instance by stimulating bifidobacteria. Further research in adults is required into HMO mechanisms, to confirm the preliminary results available to date and recommendations of HMO use in IBS. |
| Databáze: | Directory of Open Access Journals |
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