Impact of novel agent therapies on immune cell subsets and infectious complications in patients with relapsed/refractory multiple myeloma

Autor: Lukas John, Kaya Miah, Axel Benner, Elias K. Mai, Katharina Kriegsmann, Michael Hundemer, Dorothee Kaudewitz, Carsten Müller-Tidow, Karin Jordan, Hartmut Goldschmidt, Marc S. Raab, Nicola Giesen
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Oncology, Vol 13 (2023)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2023.1078725
Popis: IntroductionInfections are a leading cause of morbidity and mortality in patients with multiple myeloma (MM). MethodsTo examine the effects of modern second-generation novel agent therapy on immune cell subsets, in particular CD4+-T-cells, and infectious complications in patients with relapsed/refractory MM (RRMM), we conducted a prospective cohort study in 112 RRMM patients. ResultsSubstantially decreased CD4+-T-cells
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