The influence of coronary stenting with rapamycin-eluting stents on the number of circulating CD4+CD25high+regulatory T-cells
| Autor: | Tat'yana Igorevna Aref'eva, Sergey Il'ich Provatorov, Aleksandra Viktorovna Potekhina, Vladimir Olegovich Sokolov, Nadezhda Borisovna Kukhtina, Anatoliy Nikolaevich Samko, Tat'yana Leonidovna Krasnikova, T I Arefieva, S I Provatorov, A V Potekhina, V O Sokolov, N B Kukhtina, A N Samko, T L Krasnikova |
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| Jazyk: | ruština |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 81, Iss 9, Pp 33-37 (2009) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim. To investigate the effects of coronary stenting with rapamycin-eluting stents on parameters of cell immunity. Methods. 26 patients (group 1) with stable coronary heart disease and angiographically proved coronary stenosis underwent stenting with rapamycin-eluting stents. The control group (group 2) consisted of 6 patients: 4 patients underwent diagnostic coronaroangiography, 1 patient got a bare metal stent and in 1 patient angioplasty was unsuccessful. Blood samples were obtained before and 1 month after the intervention. The quantity of activated (CD4+CD25low+) and regulatory (CD4+CD25high+) T cells was measured by direct immunofluorescence and flow cytometry. Plasma concentration of IL-10 was determined by ELISA. Results. In group 1 the percentages of CD4+CD25high+ regulatory T-cells increased significantly one month after stenting, while in group 2 no difference in regulatory T-cell levels before and after the intervention was observed. No changes in total number of leukocytes, relative levels of lymphocytes, CD4+ T-cells, activated CD4+CD25+low T-cells and IL-10 plasma concentration before and after the procedure were detected in both groups. Conclusion. Rapamycin-eluting stent implantation is associated with a significant increase of circulating CD4+CD25high+ regulatory T-cell level. |
| Databáze: | Directory of Open Access Journals |
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