Therapeutic significance of vitamin D and calcium in reducing the risk of preeclampsia
| Autor: | E. N. Vasilyeva, L. I. Maltseva, T. G. Denisova, L. I. Gerasimova |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Акушерство, гинекология и репродукция, Vol 13, Iss 2, Pp 103-110 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2313-7347 2500-3194 |
| DOI: | 10.17749/2313-7347.2019.13.2.103-110 |
| Popis: | Aim: to study the possibility of reducing the incidence of preeclampsia (PE) by giving vitamin D and calcium (Ca) to pregnant women with a high PE risk starting from the second trimester of pregnancy.Materials and methods. A total of 101 patients from the PE high risk group were examined on weeks 14–16 of pregnancy followed by treatment with vitamin D and Ca; then, the course of pregnancy and labor was analyzed. Serum 25-hydroxycholecalciferol, vitamin D binding protein, endothelin 1-38, and ionized Ca were determined using enzyme immunoassays.Results. In the examined women at high risk of PE, severe serum deficiency of vitamin D and Ca was detected. In patients treated with vitamin D and Ca, a two-fold decrease in the incidence of PE, a three-fold decrease in the incidence of intrauterine growth retardation syndrome, and a decrease in the number of urgent surgery-assisted deliveries were found.Conclusion. Therapy with vitamin D and Ca from the second trimester of pregnancy increases the availability of vitamin D, leads to a more favorable course of pregnancy, and prevents the development of severe forms and early onset of PE in patients at high risk. |
| Databáze: | Directory of Open Access Journals |
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