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Purpose. While unicompartmental knee arthroplasty (UKA) has demonstrated benefits over total knee arthroplasty (TKA) in selected populations, component placement continues to be challenging with conventional surgical instruments, resulting in higher early failure rates. Robotic-arm-assisted UKA (RA-UKA) has shown to be successful in component positioning through preop planning and intraop adjustability. The purpose of this study is to assess the 5-year clinical outcomes of medial RA-UKA. Methods. This study was a retrospective review of a single-center prospectively maintained cohort of 133 patients (146 knees) indicated for medial UKA from 2009 to 2013. Perioperative data and 2- and 5-year Knee injury Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Score (WOMAC), and Forgotten Joint Score (FJS) outcome measures were collected. Five-year follow-up was recorded in 119 patients (131 knees). Results. Mean follow-up was 5.1±0.2 years. Mean age and BMI were 68.0±8.1 years and 29.3±4.7 kg/m2, respectively. At 2-year follow-up, mean KOOS, WOMAC, and FJS were 71.5±15.3, 14.3±7.9, and 79.1±25.8, respectively. At 5-year follow-up, mean KOOS, WOMAC, and FJS were 71.6±15.2, 14.2±7.9, and 80.9±25.1, respectively. Mean change in KOOS and WOMAC was 34.6±21.4 and 11.0±13.6, respectively (p |