Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue

Autor: Benjamin Lochocki, Baayla D. C. Boon, Sander R. Verheul, Liron Zada, Jeroen J. M. Hoozemans, Freek Ariese, Johannes F. de Boer
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-01981-x
Popis: Lochocki et al. report detection of amyloid plaques by label-free fluorescence and Raman imaging in snap-frozen frontal cortex tissue from Alzheimer’s disease cases. They identify presence of carotenoid in a cored amyloid plaque area, versus a non-plaque area, suggesting a distinct neuroinflammatory response to misfolded protein aggregations.
Databáze: Directory of Open Access Journals
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