Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells

Autor: Huda I. Atiya, Grace Gorecki, Geyon L. Garcia, Leonard G. Frisbie, Roja Baruwal, Lan Coffman
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Biomolecules, Vol 13, Iss 11, p 1604 (2023)
Druh dokumentu: article
ISSN: 13111604
2218-273X
DOI: 10.3390/biom13111604
Popis: The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell–cell adhesion and the acquisition of motile and stem-like phenotypes. A critical modulator of EMT in cancer cells is the stromal tumor microenvironment (TME), which can promote the acquisition of a mesenchymal phenotype through direct interaction with cancer cells or changes to the broader microenvironment. In this review, we will explore the role of stromal cells in modulating cancer cell EMT, with particular emphasis on the function of mesenchymal stromal/stem cells (MSCs) through the activation of EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune cell alteration, and metabolic rewiring.
Databáze: Directory of Open Access Journals
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