| Autor: |
Polly Soo Xi Yap, Chun Wie Chong, Sasheela Ponnampalavanar, Ramliza Ramli, Azian Harun, Tengku Zetty Maztura Tengku Jamaluddin, Anis Ahmed Khan, Soo Tein Ngoi, Yee Qing Lee, Min Yi Lau, Shiang Chiet Tan, Zhi Xian Kong, Jia Jie Woon, Siew Thong Mak, Kartini Abdul Jabar, Rina Karunakaran, Zalina Ismail, Sharifah Azura Salleh, Siti Suraiya Md Noor, Siti Norbaya Masri, Niazlin Mohd Taib, Azmiza Syawani Jasni, Loong Hua Tee, Kin Chong Leong, Victor Kok Eow Lim, Sazaly Abu Bakar, Cindy Shuan Ju Teh |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
PeerJ, Vol 11, p e16393 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2167-8359 |
| DOI: |
10.7717/peerj.16393 |
| Popis: |
Background The high burden of extended-spectrum beta-lactamase-producing (ESBL)-producing Enterobacterales worldwide, especially in the densely populated South East Asia poses a significant threat to the global transmission of antibiotic resistance. Molecular surveillance of ESBL-producing pathogens in this region is vital for understanding the local epidemiology, informing treatment choices, and addressing the regional and global implications of antibiotic resistance. Methods Therefore, an inventory surveillance of the ESBL-Escherichia coli (ESBL-EC) isolates responsible for infections in Malaysian hospitals was conducted. Additionally, the in vitro efficacy of flomoxef and other established antibiotics against ESBL-EC was evaluated. Results A total of 127 non-repetitive ESBL-EC strains isolated from clinical samples were collected during a multicentre study performed in five representative Malaysian hospitals. Of all the isolates, 33.9% were isolated from surgical site infections and 85.8% were hospital-acquired infections. High rates of resistance to cefotaxime (100%), cefepime (100%), aztreonam (100%) and trimethoprim-sulfamethoxazole (100%) were observed based on the broth microdilution test. Carbapenems remained the most effective antibiotics against the ESBL-EC, followed by flomoxef. Antibiotic resistance genes were identified by PCR. The blaCTX-M-1 was the most prevalent ESBL gene, with 28 isolates (22%) harbouring blaCTX-M-1 only, 27 isolates (21.3%) co-harbouring blaCTX-M-1 and blaTEM, and ten isolates (7.9%) co-harbouring blaCTX-M-1, blaTEM and blaSHV. A generalised linear model showed significant antibacterial activity of imipenem against different types of infection. Besides carbapenems, this study also demonstrated a satisfactory antibacterial activity of flomoxef (81.9%) on ESBL-EC, regardless of the types of ESBL genes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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