Splenectomy with Portoazygous Disconnection for Correction of Systemic Hemodynamic Disorders in Hepatic Cirrhosis Patients with Portal Hypertension: A Prospective Single-Center Cohort Study

Autor: Dao-Bing Zeng, Liang Di, Qing-Liang Guo, Jing Ding, Xiao-Fei Zhao, Shi-Chun Lu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Canadian Journal of Gastroenterology and Hepatology, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2291-2789
2291-2797
DOI: 10.1155/2020/8893119
Popis: Objective. To investigate the effect of splenectomy for correction of systemic hemodynamic disorders in hepatic cirrhosis patients with portal hypertension. Methods. Hepatic cirrhosis patients with portal hypertension were enrolled from April 2015 to July 2018. Systemic hemodynamic parameters (heart rate, mean arterial pressure (MAP), cardiac output, and total peripheral vascular resistance (TPR)) were prospectively measured at baseline and 1 week, 1, 3, and 6 months, and 1, 2, and 3 years postoperatively. Paired analysis was conducted. Results. Sixty-nine patients were eligible, and 55 (79.7%) cases had a history of upper gastrointestinal bleeding. Child–Pugh classification was grade A in 41 (59.4%) cases, grade B in 26 (37.7%) cases, and grade C in 2 (2.9%) cases. The heart rate was significantly higher at 1 week postoperatively versus the baseline (P
Databáze: Directory of Open Access Journals
Externí odkaz: