L-Cysteine Partially Protects Against Acrylamide-Induced Testicular Toxicity
| Autor: | Sedat Kaçar, Varol Şahintürk, Betül Can, Ahmet Musmul |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Balkan Medical Journal, Vol 35, Iss 4, Pp 311-319 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2146-3123 2146-3131 |
| DOI: | 10.4274/balkanmedj.2017.0830 |
| Popis: | Background: Acrylamide is a widespread substance with many areas of utilization. Acrylamide also forms a part of high-temperature-processed starchy foods. To date, numerous in vivo and in vitro studies have documented that acrylamide poses toxic effects on various organ systems. Aims: To determine the potential protective effect of L-cysteine on acrylamide-induced testicular toxicity. Study Design: Animal experimentation. Methods: We randomly divided 28 rats into four groups: control (0.9% saline), L-cysteine (150 mg/kg), acrylamide (40 mg/kg), and acrylamide+L-cysteine. After a 10-day intraperitoneal injection period, we euthanized the animals, recorded their body and testis weights, collected blood samples for serum testosterone measurement, and excised the testes for histopathological and morphometric evaluation. Immunohistochemical scoring of proliferating cell nuclear antigen and bax proteins was performed. Results: Acrylamide reduced body (p |
| Databáze: | Directory of Open Access Journals |
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