Calciphylaxis and its diagnosis: A review

Autor: Deepak Baby, Meenakshi Upadhyay, M Derick Joseph, Swati Joshi Asopa, Basanta Kumar Choudhury, Jagadish Prasad Rajguru, Shivangi Gupta
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Family Medicine and Primary Care, Vol 8, Iss 9, Pp 2763-2767 (2019)
Druh dokumentu: article
ISSN: 2249-4863
11586982
DOI: 10.4103/jfmpc.jfmpc_588_19
Popis: Calciphylaxis also known as Calcific uremic arteriolopathy (CUA), is a rare fatal complication usually associated with end-stage renal disease (ESRD). It is characterized by skin ulceration and necrosis leading to significant pain. The disease calciphylaxis is pathological state resulting in accumulation of calcium content in medial wall of small blood vessels along with the fibrotic changes in intima. The aetiopathogenesis of this disease, small vessel vasculopathy, remains complicated, and unclear. It is believed that development of calciphylaxis depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion. The disease is rare, life-threatening medical condition that occurs mostly in population with kidney disease or in patients on dialysis. Skin biopsy and radiographic features are helpful in the diagnosis of calciphylaxis, but negative results do not necessarily exclude the diagnosis. This article highlights steps undertaking in the diagnosis of calciphylaxis.
Databáze: Directory of Open Access Journals
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