| Autor: |
Hibiki Kudamatsu, Takehiro Kawashiri, Keisuke Mine, Kohei Mori, Mizuki Inoue, Haruna Ishida, Mayako Uchida, Takashi Tsuchiya, Daisuke Kobayashi, Takao Shimazoe |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacological Sciences, Vol 152, Iss 3, Pp 163-166 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2023.04.008 |
| Popis: |
Cachexia is a common cancer complication and is associated with weight loss and anorexia. In this study, we investigated the ameliorating effects of cystine and theanine on cancer cachexia using a mouse model. In mice carrying the colon cancer cell line C-26, there was a suppression of body weight increase and reduction in both internal fat and lower limb muscles. Repeated cystine and theanine administration significantly prevented weight loss, internal fat loss, lower limb muscle loss, and serum IL-6 increase in the cachexia model. These results suggested that cystine and theanine may be effective in ameliorating cancer cachexia. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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