Effect of central administration of indomethacin on anandamide-induced GnRH/LH secretion in the hypothalamus of anoestrous ewes

Autor: Tomaszewska-Zaremba Dorota, Tomczyk Monika, Wojtulewicz Karolina, Bochenek Joanna, Pałatyńska Kinga, Herman Andrzej Przemysław
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Veterinary Research, Vol 68, Iss 3, Pp 451-459 (2024)
Druh dokumentu: article
ISSN: 2450-8608
DOI: 10.2478/jvetres-2024-0039
Popis: It is suggested that cannabinoids (CBs) may disturb reproduction through action on hypothalamic gonadotropin-releasing hormone (GnRH) neurons directly or indirectly through intermediates such as prostaglandins. The study aimed to determine the influence of intracerebroventricular (i.c.v.) injection of the endogenous cannabinoid anandamide (N-arachidonoylethanolamine – AEA), alone or with the prostaglandin synthesis inhibitor indomethacin (IND), on GnRH/luteinising hormone (LH) secretion. The purpose of the research was to clarify the role of endocannabinoids and their interaction with prostaglandins in the regulation of reproduction at the level of the hypothalamus and pituitary in anoestrous sheep.
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