Clinical features and 1-year outcomes of variable obstruction in participants with preserved spirometry: results from the ECOPD study in China

Autor: Zihui Wang, Shuqing Yu, Haiqing Li, Fan Wu, Ningning Zhao, Pixin Ran, Yumin Zhou, Xiaohui Wu, Qi Wan, Youlan Zheng, Jieqi Peng, Zhishan Deng, Huajing Yang, Shan Xiao, Xiang Wen, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Ruiting Sun, Changli Yang, Shengtang Chen, Jianhui Huang, Gaoying Tang, Jiangyu Cui
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2052-4439
DOI: 10.1136/bmjresp-2023-002210
Popis: Background There are limited data on the clinical features and longitudinal prognosis of variable obstruction, particularly among never smokers and different variable obstruction types. Therefore, we aimed to evaluate the clinical characteristics of the participants with variable obstruction and determine the relationship between variable obstruction and the development of chronic obstructive pulmonary disease (COPD) and the decline of lung function in a community-dwelling study of Chinese, especially among never smokers and different variable obstruction subtypes.Methods Participants with preserved spirometry (postbronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥0.70) at baseline from the Early COPD cohort were included in our analysis. Participants with variable obstruction (prebronchodilator FEV1/FVC
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