Automated optimisation of solubility and conformational stability of antibodies and proteins

Autor: Angelo Rosace, Anja Bennett, Marc Oeller, Mie M. Mortensen, Laila Sakhnini, Nikolai Lorenzen, Christian Poulsen, Pietro Sormanni
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Druh dokumentu: article
ISSN: 2041-1723
22796517
DOI: 10.1038/s41467-023-37668-6
Popis: Antibodies find key applications in research, diagnostics, and therapeutics, but their development can be impeded by poor stability or solubility. Here the authors developed a computational strategy that enables antibody optimisation, without affecting functionality.
Databáze: Directory of Open Access Journals
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