Risk Factors of Cognitive Frailty in Hospitalized Older Patients with Comorbidities and Its Implication for Patient Outcomes

Autor: YAN Xuedan, CHEN Shanping, ZHOU Lihua, WANG Lingxiao, YANG Yongxue, REN Yan
Jazyk: čínština
Rok vydání: 2022
Předmět:
Zdroj: Zhongguo quanke yixue, Vol 25, Iss 31, Pp 3877-3883 (2022)
Druh dokumentu: article
ISSN: 1007-9572
DOI: 10.12114/j.issn.1007-9572.2022.0154
Popis: Background Cognitive frailty is a cognitive impairment state between normal aging and dementia. Cognitive frailty is associated with higher possibility of negative clinical events than simple frailty or cognitive impairment in older people. As cognitive frailty could be reversible toa certain degree, early identification of high-risk groups and timely intervention are particularly important in reducing adverse prognoses and improving the quality of life of elderly patients in their later years. Objective To investigate the prevalence and influencing factors of cognitive frailty, and its relationship with two-year post-discharge mortality in hospitalized elderly patients with comorbidities. Methods The data were collected from part of the project "Research and Demonstration of Clinical Management and Community-based Continuing Care Models for Older People with Comorbidities", involving a cluster sample of older inpatients with comorbidity aged≥60 years recruited from Department of Gerontology, Chengdu Fifth People's Hospital from November 2015 to January 2018. Demographics, chronic disease prevalence, and comprehensive geriatric assessment results were collected. Cognitive frailty was assessed by the FRAIL scale and Mini-Mental State Examination. Binary Logistic regression was used to analyze the influencing factors of cognitive frailty. The survival status was investigated at the end of a two-year follow-up after discharge. Cox regression was used to analyze the relationship of cognitive frailty with two-year post-discharge mortality. Results A total of 554 cases were included, and 15.9% (88/554) of them had cognitive frailty. Compared with non-cognitive frailty group, cognitive frailty group had older average age, lower prevalence of high school education or above, lower average family care score, higher prevalence of malnutrition, depression, dependence in activities of daily living and balance dysfunction (P
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