Photodynamic therapy in tuberculous pleural empyema

Autor: S. D. Nikonov, M N. Smolentsev, D. V. Krasnov, D. А. Bredikhin, S. N. Belogorodtsev
Jazyk: ruština
Rok vydání: 2021
Předmět:
Zdroj: Туберкулез и болезни лёгких, Vol 99, Iss 5, Pp 51-56 (2021)
Druh dokumentu: article
ISSN: 2075-1230
2542-1506
DOI: 10.21292/2075-1230-2021-99-5-51-56
Popis: as a lethal outcome predictor. To enhance treatment efficacy, TPE local sanitation method utilizing antimicrobial photodynamic therapy (PDT) has been developed. This technique is based on the generation of oxygen radicals by the interaction of photosensitizers and light quanta which inactivate Mycobacterium tuberculosis and pyogenic flora. To assess the sanitizing and antimicrobial efficacy of PDT, 96 procedures were performed in 16 patients (in 14 cases, TPE was complicated by bronchopleural fistula, in 10 cases it developed after surgical treatment of pulmonary tuberculosis). After intrapleural instillation of phthalocyanine aluminum 0.5 mg, all walls of the empyema cavity were irradiated by laser radiation with the wavelength of 662 nm and light density of 30-100 J/cm2. The response to PDT of tuberculous pleural empyema was reported in 93.75% of cases (n = 15), with complete response observed in 75% of cases (n = 12).
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