Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults

Autor:	Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee
Jazyk:	English<br />Korean
Rok vydání:	2021
Předmět:	sarcopenia osteoporosis aging diagnostic screening programs computed tomography Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Endocrinology and Metabolism, Vol 36, Iss 6, Pp 1201-1210 (2021)
Druh dokumentu:	article
ISSN:	2093-596X 2093-5978
DOI:	10.3803/EnM.2021.1206
Popis:	Background A decrease in computed tomography (CT)-derived skeletal muscle radiodensity (SMD) reflects age-related ectopic fat infiltration of muscle, compromising muscle function and metabolism. We investigated the age-related trajectory of SMD and its association with vertebral trabecular bone density in healthy adults. Methods In a cohort of healthy adult kidney donors aged 19 to 69 years (n=583), skeletal muscle index (SMI, skeletal muscle area/height2), SMD, and visceral-to-subcutaneous fat (V/S) ratio were analyzed at the level of L3 from preoperative CT scans. Low bone mass was defined as an L1 trabecular Hounsfield unit (HU)
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/11285a4841d746be855edf76c8ac4fa9 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF