Simultaneous presentation of idiopathic uveitis in monozygotic 4-year-old twin boys

Autor: Sarah Baxter, Russell N. Van Gelder, Jason C. Cheung, Matthew L. Basiaga
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: American Journal of Ophthalmology Case Reports, Vol 27, Iss , Pp 101666- (2022)
Druh dokumentu: article
ISSN: 2451-9936
DOI: 10.1016/j.ajoc.2022.101666
Popis: Purpose: To report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis with simultaneous onset. Observations: Here we report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis. The boys had simultaneous onset of uveitis and identical features. Evaluation, including whole exome sequencing (WES), failed to reveal a specific causative etiology. Each patient responded well to immune modulation and achieved uveitis remission on methotrexate monotherapy off topical glucocorticoids. Conclusions and Importance: From this case of monozygotic twin boys presenting with chronic uveitis, we conclude that monozygotic twins may warrant evaluation in the setting of idiopathic uveitis, especially in young patients unable to express an adequate history.
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