Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures

Autor: Ya-Wu Zhang, Feng-Xian Wei, Xue-Ping Qi, Zhao Liu, Xiao-Dong Xu, You-Cheng Zhang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Gastroenterology Research and Practice, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1687-6121
1687-630X
DOI: 10.1155/2018/7619298
Popis: Objectives. To evaluate the efficacy and safety of endoscopic intralesional triamcinolone injection (ITI) for benign esophageal strictures combined with endoscopic dilation (ED). Methods. Online databases including MEDLINE, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for prospective randomized control trials (RCTs) between 1966 and March 2018. A meta-analysis was conducted according to the methods recommended by the Cochrane Collaboration. Results. Six RCTs consisting of 176 patients were selected. Meta-analysis results showed that additional ITI had a significant advantage in terms of stricture rate and required ED sessions. Surgery-related and non-surgery-related strictures showed similar results. Additional ITI was not associated with significantly increased risk of complications. Conclusions. Our meta-analysis showed that additional ITI therapy was supposed to be effective and safe for benign esophageal strictures as it reduced the stricture rate and required ED sessions. However, more RCTs are necessary to support these findings.
Databáze: Directory of Open Access Journals
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