THE EFFECTIVENESS OF INTRA-ARTICULAR INJECTIONS HYALURONIC ACID AND CORTICOSTEROIDS IN THE TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS SYMPTOMS

Autor: Syed Muhammad Shabbir Ali Naqvi, Fatima Ihsan, Kumail Ijaz, Muhammad Usama, Faizan Ur Rehman Barki, Amjad Ali
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Rehman Journal of Health Sciences, Vol 4, Iss 2, Pp 90-95 (2023)
Druh dokumentu: article
ISSN: 2664-4630
2708-2512
DOI: 10.52442/rjhs.v4i2.89
Popis: Introduction: Knee osteoarthritis (OA) is a degenerative condition that is caused by the gradual wear and tear of the cartilage that cushions the bones of the knee. This study will find out the effectiveness of intra-articular hyaluronic acid (IAHA) and intra-articular corticosteroids (IACS) in the management of knee OA. Material & Methods: A randomized control trial was conducted in Hayatabad Medical Complex Peshawar and Pak Military Hospital Rawalpindi from March 2019 to June 2021. Total one eighty-two patients were randomly assessed in the study. Treatment group A received intra-articular hyaluronic acid (IAHA), while treatment group B received intra-articular corticosteroids for three months. This study has used Western Ontario and McMaster Universities Arthritis Index (WOMAC) to evaluate the effectiveness of treatment in both groups of knee OA. Results: The study participants mean age was 56.344 ± 7.25. Out of 182 patients, 2 of the patients reported as “loss to follow up” from IACS Tx group b. Treatment groups include 95 (52.7%) female patient while 85 (47.22%) were male patients. 96 (53.33%) received intra-articular hyaluronic acid (IAHA), while 84 (46.66%) received intra-articular steroids (IACS). The pre- and post-treatment mean difference in WOMAC scores in the hyaluronic acid group was 5.52 ± 4.756, while that in the corticosteroid group was 9.495 ± 1.24 (p value < 0.01). Conclusion: Intra-articular steroids (IACS) and hyaluronic acid (IAHA) alone reduces OA symptoms and pain significantly. Yet intra-articular steroids are more effective than intra-articular hyaluronic acid in reducing symptoms of OA at knee.
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