A Systematic Review on the Risk Modulators of Myocardial Infarction in the 'Young'—Implications of Lipoprotein (a)

Autor: Cristian Stătescu, Larisa Anghel, Laura-Cătălina Benchea, Bogdan-Sorin Tudurachi, Andreea Leonte, Alexandra Zăvoi, Ioana Mădălina Zota, Cristina Prisacariu, Rodica Radu, Ionela-Lăcrămioara Șerban, Radu Andy Sascău
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 24, Iss 6, p 5927 (2023)
Druh dokumentu: article
ISSN: 24065927
1422-0067
1661-6596
DOI: 10.3390/ijms24065927
Popis: The presence of a myocardial infarction at a younger age is of special interest, considering the psychological and socioeconomic impact, as well as long-term morbidity and mortality. However, this group has a unique risk profile, with less traditional cardiovascular risk factors that are not well studied. This systematic review aims to evaluate traditional risk factors of myocardial infarction in the “young”, highlighting the clinical implications of lipoprotein (a). We performed a comprehensive search using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards; we systematically searched the PubMed, EMBASE, and Science Direct Scopus databases, using the terms: “myocardial infarction”, “young”, “lipoprotein (a)”, “low-density lipoprotein”, “risk factors”. The search identified 334 articles which were screened, and, at the end, 9 original research articles regarding the implications of lipoprotein (a) in myocardial infarction in the “young” were included in the qualitative synthesis. Elevated lipoprotein (a) levels were independently associated with an increased risk of coronary artery disease, especially in young patients, where this risk increased by threefold. Thus, it is recommended to measure the lipoprotein (a) levels in individuals with suspected familial hypercholesterolaemia or with premature atherosclerotic cardiovascular disease and no other identifiable risk factors, in order to identify patients who might benefit from a more intensive therapeutic approach and follow-up.
Databáze: Directory of Open Access Journals
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