Breast milk vitamin B12 concentration and incidence of diarrhea and respiratory infections among infants in urban Tanzania: a prospective cohort study

Autor: Omar N. Lweno, Christopher R. Sudfeld, Ellen Hertzmark, Karim P. Manji, Anne Marie Darling, Wafaie W. Fawzi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Research Notes, Vol 13, Iss 1, Pp 1-5 (2020)
Druh dokumentu: article
ISSN: 1756-0500
DOI: 10.1186/s13104-020-05003-7
Popis: Abstract Objective A recent trial of vitamin B12 supplementation among Indian children 6–30 months found no effect on the incidence of diarrhea and respiratory infections. These results differ with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania. Results A prospective cohort study was undertaken to determine the association of breast milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had breast milk vitamin B12 inadequacy (
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