| Autor: |
Gaurav Kumar, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Michel Ticchioni, Pierre-Marie Roger |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Infectious Disease Reports, Vol 13, Iss 1, Pp 72-81 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2036-7449 |
| DOI: |
10.3390/idr13010009 |
| Popis: |
Idiopathic CD4 T cell lymphocytopenia (ICL) is a rare entity characterized by CD4 T cell count of 3 along with opportunistic infection for which T cell marker expression remains to be fully explored. We report an ICL case for which T lymphocyte phenotype and its costimulatory molecules expression was analyzed both ex vivo and after overnight stimulation through CD3/CD28. The ICL patient was compared to five healthy controls. We observed higher expression of inhibitory molecules PD-1/PDL-1 and CTLA-4 on CD4 T cells and increased regulatory T cells in ICL, along with high activation and low proliferation of CD4 T cells. The alteration in the expression of both the costimulatory pathway and the apoptotic pathway might participate to down-regulate both CD4 T cell functions and numbers observed in ICL. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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