Curcumin attenuates sensorimotor deficits induced by selective neuronal loss: A study in middle cerebral artery occlusionrat model of transient ischemic stroke.
| Autor: | Mufzala Shamim, Nazish Iqbal Khan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Endorsing Health Science Research, Vol 8, Iss 4, Pp 212-222 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2307-3748 2310-3841 |
| DOI: | 10.29052/IJEHSR.v8.i4.2020.212-222 |
| Popis: | Background:Ischemic stroke is the most prevalent and major pathological stroke type.Increased systemic oxidative stressis a crucialunderlyingpathophysiological mechanismof ischemic stroke.In this regard, therapeutic interventions targeting oxidative stress management would be a promising avenue. Curcumin is well recognized to counteract various pathologieseffectively.The present study was designed to investigate the neuroprotective effects of curcumin against ischemia-reperfusion injury-induced selective neuronal damage. Methodology:Present study employed an ischemic brain injury model induced by middle cerebral artery occlusion (MCAO) inWistar albino rats. Experimental groups (n=36; age-matched, female, weighing 200-240 g) were control, sham-operated, MCAO (15 min occlusion + 24 hrs.reperfusion) and curcumin-treated pre-stroke group (received curcumin 300 mg/kg body weight/day, I/P, for30 days followed by MCAO). With the completion of the experimental protocol, sensorimotor deficits were examined by behavioral tests, including neurological deficit score, foot fault test, forelimb placing test, corner turn test, and wire hanging test. Results:Compared to MCAO rats, curcumin-treated MCAO rats showedbetter neurological functioning (p |
| Databáze: | Directory of Open Access Journals |
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