Eight challenges in phylodynamic inference
| Autor: | Simon D.W. Frost, Oliver G. Pybus, Julia R. Gog, Cecile Viboud, Sebastian Bonhoeffer, Trevor Bedford |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Epidemics, Vol 10, Iss C, Pp 88-92 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1755-4365 1878-0067 |
| DOI: | 10.1016/j.epidem.2014.09.001 |
| Popis: | The field of phylodynamics, which attempts to enhance our understanding of infectious disease dynamics using pathogen phylogenies, has made great strides in the past decade. Basic epidemiological and evolutionary models are now well characterized with inferential frameworks in place. However, significant challenges remain in extending phylodynamic inference to more complex systems. These challenges include accounting for evolutionary complexities such as changing mutation rates, selection, reassortment, and recombination, as well as epidemiological complexities such as stochastic population dynamics, host population structure, and different patterns at the within-host and between-host scales. An additional challenge exists in making efficient inferences from an ever increasing corpus of sequence data. |
| Databáze: | Directory of Open Access Journals |
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