Polyclonal Burkholderia cepacia Complex Outbreak in Peritoneal Dialysis Patients Caused by Contaminated Aqueous Chlorhexidine
| Autor: | Sally C.Y. Wong, Shuk-Ching Wong, Jonathan H.K. Chen, Rosana W.S. Poon, Derek L.L. Hung, Kelvin H.Y. Chiu, Simon Y.C. So, Wing Shan Leung, Tak Mao Chan, Desmond Y.H. Yap, Vivien W.M. Chuang, Kwok-Yung Yuen, Vincent C.C. Cheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 26, Iss 9, Pp 1987-1997 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid2609.191746 |
| Popis: | Whether Burkholderia cepacia complex should be an objectionable organism in antiseptic solutions with acceptable total bacterial counts is controversial. By using next-generation sequencing, we documented a polyclonal B. cepacia complex outbreak affecting peritoneal dialysis patients in Hong Kong that was caused by contaminated chlorhexidine solutions. Epidemiologic investigations at a manufacturing site identified a semiautomated packaging machine as the probable source of contamination in some of the brands. Use of whole-genome sequencing differentiated the isolates into 3 brand-specific clonal types. Changes in exit site care recommendations, rapid recall of affected products, and tightening of regulatory control for chlorhexidine-containing skin antiseptics could prevent future similar outbreaks. Environmental opportunistic pathogens, including B. cepacia complex, might be included in regular surveillance as indicator organisms for monitoring environmental contamination. |
| Databáze: | Directory of Open Access Journals |
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