TIMP2 promotes intramuscular fat deposition by regulating the extracellular matrix in chicken

Autor: Huan-xian CUI, Na LUO, Li-ping GUO, Lu LIU, Si-yuan XING, Gui-ping ZHAO, Jie WEN
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Integrative Agriculture, Vol 22, Iss 3, Pp 853-863 (2023)
Druh dokumentu: article
ISSN: 2095-3119
DOI: 10.1016/j.jia.2022.08.071
Popis: The interaction between myocytes and intramuscular adipocytes is a hot scientific topic. Using a co-culture system, this study aims to investigate the regulation of intramuscular fat deposition in chicken muscle tissue through the interaction between myocyte and adipocyte and identify important intermediary regulatory factors. Our proteomics data showed that the protein expression of tissue inhibitor of metalloproteinases 2 (TIMP2) increased significantly in the culture medium of the co-culture system, and the content of lipid droplets was more in the co-culture intramuscular adipocytes. In addition, TIMP2 was significantly upregulated (P
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