Synthesis of New Spiro-Cyclopropanes Prepared by Non-Stabilized Diazoalkane Exhibiting an Extremely High Insecticidal Activity

Autor:	Naoufel Ben Hamadi, Ahlem Guesmi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	1 3-dipolar cycloaddition photolysis 1H-pyrazole spiro-cyclopropane docking insecticides Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 8, p 2470 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27082470
Popis:	The synthesis of new insecticidal gem-dimethyspiro-cyclopropanes derived from pyrrolidine-2,3-dione have been described, and their biological effect against different insect species has been evaluated. The presented results demonstrate the excellent insecticidal activity of cyclopropane 5c against Aedes aegypti and Musca domestica. Cyclopropane 5c showed the quickest knockdown and the best killing against Aedes aegypti and Musca domestica compared to trans-chrysanthemic acid and pyrethrin. The biological results of the high insecticidal activity were confirmed by the results of docking. This is evident in the binding affinity obtained for cyclopropane 5c, indicating good binding with an important active amino acid residue of the 5FT3 protein.
Databáze:	Directory of Open Access Journals
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